We've all heard the nicknames "TomKat," "Brangelina" and "Vaughniston," but don't let the word play fool you. People magazine's Senior Editor Galina Espinoza told us that Tom and Katie, Brad and Angelina and Vince and Jen are among Hollywood's most powerful couples.

But coming in at number five is super couple Marc Anthony and Jennifer Lopez. With movies, music and fashion, this duo has all of the markets covered, and they're just getting started.

"They have not only their shared heritage that bonds them together, but also their shared ambition," Galina said.

The original Mr. and Mrs. Smith -- Will and Jada -- come at number four. For Will Smith and Jada Pinkett Smith, the key is planning.

"Certainly Will Smith would say that one of the keys to keeping his marriage together is that he and Jada really take turns working," Espinoza said. "They don't go off and do separate projects because they know about all the temptations of being apart, so they work hard at being together as a family."

Our number three couple is Michael Douglas and Catharine Zeta-Jones, who between them has three Oscars, countless homes and a lot of money.

"Michael and Catherine are estimated to be worth more than $200 million," Espinoza revealed.

The number two spot goes to none other than Tom Cruise and Katie Holmes. "I think that power in Hollywood is best captured by Tom Cruise," Espinoza said. "This is a man who not only rules the box office, but he can get the Eiffel Tower reopened after hours so he can propose to Katie Holmes. I mean very few people in the world can do that."

But the Brangelina effect secures the top spot for Brad Pitt and Angelina Jolie. She donates a third of her salary to charity, and he's joined forces with her to save the world one forgotten child at a time.

"Brad and Angelina have really set a new standard for what it means to be a humanitarian-minded couple," Espinoza said. "And I think people are really drawn to their love story and this new family that they've created."

There's more to come after Baby Shiloh -- Brangelina plans to adopt again, and on the heels of their "Mr. and Mrs. Smith" success, word is they're even thinking about re-teaming on the big screen.