Album of the Year
- How to Dismantle an Atomic Bomb, U2

Record of the Year
- "Boulevard of Broken Dreams," Green Day

Song of the Year
- "Sometimes You Can't Make It on Your Own," U2

Best New Artist
- John Legend

Best Pop Album
- Breakaway, Kelly Clarkson

Best Female Pop Vocal Performance
- "Since U Been Gone," Kelly Clarkson

Best Male Pop Vocal Performance
- "From the Bottom of My Heart," Stevie Wonder

Best Pop Performance by a Duo of Group
- "This Love," Maroon 5

Best Pop Collaboration With Vocals
- "Feel Good Inc.," Gorillaz featuring De La Soul

Best Solo Rock Vocal Performance
- "Devils & Dust," Bruce Springsteen

Best Rock Performance By a Duo or Group
- "Sometimes You Can't Make It On Your Own," U2

Best Rock Song
- "City Of Blinding Lights," U2

Best Rock Album
- How To Dismantle An Atomic Bomb, U2

Best Alternative Music Album
- Get Behind Me Satan, The White Stripes

Best Female R&B Vocal Performance
- "We Belong Together," Mariah Carey

Best Male R&B Vocal Performance
- "Ordinary People," John Legend

Best R&B Song
- "We Belong Together," J. Austin, M. Carey, J. Dupri & M. Seal, songwriters; (D. Bristol, K. Edmonds, S. Johnson, P. Moten, S. Sully & B. Womack, songwriters) (Mariah Carey)

Best Contemporary R&B Album
- "The Emancipation of Mimi," Mariah Carey

Best R&B Performance By a Duo or Group
- "So Amazing," Beyonce & Stevie Wonder

Best R&B Album
- Get Lifted, John Legend

Best Female Country Vocal Performance
- "The Connection," Emmylou Harris

Best Male Country Vocal Performance
- "You'll Think of Me," Keith Urban

Best Country Song
- "Bless the Broken Road," Bobby Boyd, Jeff Hanna & Marcus Hummon, songwriters (Rascal Flatts)

Best Country Album
- Lonely Runs Both Ways, Alison Krauss and Union Station

Best Rap Solo Performance
- "Gold Digger," Kanye West

Best Rap Song
- Diamonds from Sierra Leone, D. Harris & Kanye West

Best Rap Performance By a Duo or Group
- "Don't Phunk With My Heart," The Black Eyed Peas

Best Rap Album
- Late Registration, Kanye West